Chromokinesin
WebAug 23, 2004 · Chromokinesins represent a family of chromosome arm-binding kinesins consisting of two distinct types of members: chromokinesins/KIF4 and the Kid … WebChromokinesins are microtubule plus end–directed motor proteins that bind to chromosome arms. In Xenopus egg cell-free extracts, Xkid and Xklp1 are essential for …
Chromokinesin
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WebSep 1, 2016 · As a vital kind of kinesin, chromokinesin functions in different kinds of cells and organisms, from nerve cells to germ cells, from Drosophila to human. We have … WebJul 1, 2005 · Figure 1 Molecular structure and cellular localization of chromokinesins. (a) Schematic domain structure of Kinesin-4 and Kinesin-10.(b) Localization of chromokinesin HKIF4A and effects on mitosis upon its loss. (top row) Human KIF4A localizes to the nucleus during interphase, associates with mitotic chromosomes during early mitosis and …
WebMar 3, 2003 · Kid is a kinesin-like DNA-binding protein known to be involved in chromosome movement during mitosis, although its actual motor function has not been demonstrated. Here, we describe the initial … WebAug 14, 2010 · Chromokinesin KIF4 appears as reduced expression in human gastric carcinoma and associates with differentiation of gastric carcinoma. Chromokinesin KIF4 is previously reported to play an intriguing role in tumorigenesis [].To investigate the critical role of chromokinesin KIF4 in human gastric cancer, we examined 23 gastric carcinoma …
WebSep 21, 2011 · Interestingly, from its positioning on the chromosome arms, Hklp2 seems to restrict spindle pole separation. In the present review, we summarize the current knowledge of the function and regulation of the different kinesins associated with chromosome arms during cell division, including Hklp2 as a novel member of this so-called chromokinesin ...
WebJul 1, 2008 · Chromokinesins are microtubule-motor molecules that possess chromatin binding activity and are important for mitotic and meiotic regulation. The chromokinesin-member Kif4A is unique in that it localizes to nucleus during interphase of the cell cycle. Kif4 deletion by gene targeting in mouse embryoni …
WebJul 24, 2024 · Here, we present a novel abscission mechanism. We identified chromokinesin KIF4A, which is adjacent to the midbody during cytokinesis, as being required for efficient abscission. KIF4A is regulated by post-translational modifications. We evaluated modification of KIF4A by the ubiquitin-like protein SUMO. We mapped lysine … the paper vhsWebOct 3, 2003 · Mitosis requires the concerted activities of multiple microtubule (MT)-based motor proteins. Here we examined the contribution of the chromokinesin, KLP3A, to mitotic spindle morphogenesis and chromosome movements in Drosophila embryos and cultured S2 cells. By immunofluorescence, KLP3A associates with nonfibrous punctae that … shuttle feeder machineWebJun 27, 2024 · The chromokinesin KIF4A associates with microtubules and contributes to chromosome segregation during mitosis. Here, we show that this function depends on a … the paper umbrellaWebApr 8, 2024 · This bias was impervious to the experimental attenuation of polar ejection forces on chromosome arms by RNAi against the chromokinesin Kif4a. Thus, kinetochore size is an important determinant of ... shuttle fg41WebJun 27, 2024 · Chromokinesin, Fe-S cluster, Genome stability INTRODUCTION Recent studies have attempted to expand the list of genes contributing to chromosome instability (CIN) in yeast. These studies resulted in the identification of many yeast CIN genes that can be organized into a number of functional groups. shuttle fh110WebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the meiotic spindle, which is self-organized in ... shuttle fg45 motherboardWebThe chromokinesins are a subgroup of kinesin motors. Chromokinesins act in various steps of mitosis, including chromosome condensation, metaphase alignment, chromosome segregation, cytokinesis and they help maintain genome stability. the paper unicorn doylestown pa