Webcisplatin-induced nephrotoxicity leading to acute kidney injury (AKI) is high. After a single dose of cisplatin, 33% of patients will develop nephrotoxicity (2). Acute kidney injury is defined as the rapid loss of renal function, and the mortality rate for all forms of AKI ranges from 20-80%, with the highest mortality in ICU patients (3). WebFeb 1, 2024 · Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor. This product is available in the following dosage forms: Powder for Solution; Solution; Before Using
科研丨CANCER RES: 肠道微生物群的破坏导致上皮性卵巢癌对顺铂 …
WebFeb 1, 2024 · Based on the constructed C57 mice with VDR knockout and VDR overexpression, we established a cisplatin-induced acute kidney injury model. 72 h after intraperitoneal injection with cisplatin, kidney injury indicators including creatinine, urea nitrogen, cystatin C, the kidney-body weight ratio and tubular injury score in KO + CP … WebOct 4, 2024 · Cisplatin (Cis-diamine dichloroplatinum (II), Pt (NH 3) 2 Cl 2 ), which exerts its anti-cancer effect by inhibiting cell division, was used in the treatment of various solid cancers including breast cancer, ovarian cancer, … onsite internship
Full article: p53 inhibition attenuates cisplatin-induced acute …
WebOct 1, 2013 · Cisplatin-induced AKI in mice Eight-week old C57BL/6 male mice, purchased from the Jackson Laboratories, were housed for one week before experiments in the animal facility of the Charlie Norwood VA Medical Center at Augusta. These mice had free access to water and regular chow. WebChemotherapeutic doses of cisplatin impair spermatogenesis and ultimately cause azoospermia and infertility in some men. The mechanism by which cisplatin damages testicular germ cells is poorly understood. Cisplatin's impact is first detected hours after exposure in the formation of DNA cross-links followed by weeks of testicular damage. … WebApr 11, 2024 · The photothermal effect and the antitumoral efficacy of the [email protected] were studied in an in vivo model of subcutaneous melanoma in C57 mice. The photothermal activity showed an increase in temperature from the normal temperature of the tumor (33.6°C) to 39.4°C, after NIR irradiation and, 55°C with NIR and [email protected] … on site inspection software