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Web11 rows · Nov 1, 2010 · How to taper off your antidepressant. Discontinuing an antidepressant medication usually involves reducing your dose in increments, allowing two to six weeks or longer between dose reductions. Your clinician can … duloxetine (Cymbalta) 12 hours. 2.5 days. desvenlafaxine (Pristiq) 12 hours. 2.5 … how to sing from your diaphragm correctly
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