WebThe surface expression of CD70 is regulated by HIF-2α and ROS levels and is a key contributor to cytokine-enhanced migration in RA FLS. This study aimed to examine the role of CD70, which is highly expressed on fibroblast-like synoviocytes (FLS), in rheumatoid arthritis (RA) patients. Web28 de nov. de 2024 · Based on these results, it is tempting to hypothesize that along with the prevention of ROS production to sustain cell survival, ... The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell, 18 (2007), pp. 4528-4542. View in Scopus Google Scholar
The RabGEF ALS2 is a hypoxia inducible target associated with
Web12 de set. de 2024 · HIF-1α is involved in the regulation of TRIM28 on DLL, Notch and VEGFR expression. ... 44 Other studies have reported that phosphorylation of TRIM28 Ser473 can also be induced by metabolic stresses through ROS and p38, both of which play important roles in VEGF-induced angiogenesis. Web15 de ago. de 2010 · Together, these findings present the first evidence that HIF-2alpha is critically involved in the ROS-regulated vascular remodeling processes. HIF-2a protein … ons number of births
硫氧还蛋白与肿瘤转移 - 豆丁网
WebIncreased ROS production can cause activation of the NF-κB pathway, upregulate adhesion molecules, inflammatory factors, and adipokines, promote the activation of platelets and white blood cells, and then promote inflammation. 31,32 ROS can also cause mitochondrial damage and apoptosis. 33 Of note, in addition to HIF-2α, other HIF subunits also have … Web2024年11月澳大利亚Victor Chang心脏研究所Richard P. Harvey团队与Vaibhao Janbandhu等人合作在Cell Stem Cell上发表题目为“Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following … Web9 de abr. de 2024 · To answer to these questions, we treated epithelial HaCaT and breast cancer MCF-7 cells with different ZnO-NR concentrations. Our results showed that ZnO-NR treatments increased cell death through ROS accumulation, HIF-1α and endothelial PAS domain protein 1 (EPAS1) activation, and induction of autophagy and mitophagy in both … ons number of businesses