Hif glut1
Web30 de out. de 2024 · These results agree with our in vitro study showing that vitamin C induced a dose - dependent decrease of HIF-1α but not HIF-2α protein level in thyroid cancer cells FTC-133 and 8305C. The decreased HIF-1α expression was correlated with reduced expression of hypoxia-related glucose transporter 1 (GLUT1) in thyroid cancer … Web16 de jun. de 2024 · Down-regulation of miR-34a significantly promoted GLUT1 expression. Knockdown of GLUT1 reduced the glycogen content in GIFT liver cells, inhibited HIF-1a …
Hif glut1
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WebHIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha … WebAbstract. Hypoxia can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) and invasion of cancer cells. However, their mechanisms remain …
Web7 de jul. de 2009 · Likewise, strong immunostaining of HIF-1α and GLUT1 was observed in glandular epithelial cells in 7 of 8 PJP colonic polyp specimens (Fig. 4 D and F). In the normal colonic mucosa specimens, weak immunohistochemical staining of HIF-1α and Glut1 was observed relative to the highly elevated levels observed in the PJS samples … Web28 de fev. de 2014 · In AML patients, high expression levels of HIF-1α and GLUT1 were associated with lack of response to chemotherapy, probably due to the higher glycolytic metabolism of resistant tumor cells [125].
Web6 de out. de 2024 · HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. ... Levels of the HIF-1α transcriptional … Web14 de ago. de 2001 · While the studies reported herein were being completed, Ivan et al. and Jaakkola et al. reported that mammalian cell lysates can hydroxylate HIF-1α at Pro-564 in vitro, which in turn promotes VHL binding.Although the HIF-1α prolyl hydroxylase has not yet been identified, this finding suggests that under hypoxic conditions, the regulated …
Web目的 探讨缺氧诱导因子-1 α(HIF-1 α)对缺氧状态下血管内皮细胞的保护机制. 方法 ①建立小鼠失血性休克模型,选取休克组与假手术组(n=3)血管内皮细胞,进行转录组测序,分析主要 …
Web29 de ago. de 2014 · In mammalian cells hypoxia stimulates Glut1 expression and glucose transport [8, 57, 58] and the Glut1 promoter has hypoxia response elements recognized by HIF-1 (hypoxia inducible factor 1) . The GLUT1 regulation by hypoxia has not been reported in crustaceans but, it is well known that in L. vannamei hypoxia induces a shift from … tru hotel knoxville turkey creekWeb22 de dez. de 2009 · HIF-1alpha plays an indispensable role in tumor formation and histogenesis. Target genes involved in glucose transport are acutely transactivated by … tru hotel in manchester nhWeb20 de jul. de 2009 · The relative expression ratio of GLUT1 mRNA in hypoxic conditions was analyzed by RT-PCR. Ten cancerous tissues collected from human colorectal cancer patients were examined. HIF-1α and HIF-2α levels were measured to indicate the degree of hypoxia, and gene expression under hypoxic conditions was determined. tru hotel in webster texasWeb16 de jun. de 2024 · Down-regulation of miR-34a significantly promoted GLUT1 expression. Knockdown of GLUT1 reduced the glycogen content in GIFT liver cells, inhibited HIF-1a gene expression, up-regulated the expression of genes involved in P53 signaling pathways (P53 and CASPASE-3 genes), and accelerated hepatocyte apoptosis under hypoxia stress. tru hotel lithia springsWeb14 de out. de 2024 · Luseogliflozin decreased HIF-1 target genes, such as the glucose transporter GLUT1 and the glycolytic enzymes HK2 and PKM, which have hypoxia … tru hotel in oxford msWeb13 de nov. de 2024 · Cancer, the main cause of human deaths in the modern world is a group of diseases. Anticancer drug discovery is a challenge for scientists because of involvement of multiple survival pathways of cancer cells. An extensive study on the regulation of each step of these pathways may help find a potential cancer target. Up … philip morris international ukraineWebAims: Much evidence suggests that increased glucose metabolism in tumor cells might contribute to the development of acquired chemoresistance. However, the molecular … tru hotel in harrisonburg virginia