Klotho alpha
WebJan 21, 2024 · Klotho encodes alpha-Klotho (αKl) that possesses a single-pass transmembrane domain and is expressed in the distal tubule of kidneys, parathyroid gland, and choroid plexus. Following studies ... WebNov 19, 2024 · The Klotho protein that was identified as the FGF23 co-receptor became known as αKlotho (encoded by the αKlotho gene; also known as KL ). βKlotho forms …
Klotho alpha
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WebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large role in the regulation of phosphate, but this is only a small portion of the significance of Klotho. Klotho is currently making headlines because it's been linked to anti ... WebKlotho, also called Klotho-alpha, is the founding member of the Klotho family within the glycosidase-1 superfamily (1, 2). Klotho is expressed in areas concerned with calcium …
WebNational Center for Biotechnology Information WebAlpha Klotho (α-Klotho) is a key player that integrates a multi-step regulatory system of calcium metabolism and phosphate homeostasis. Alpha Klotho (α-Klotho) was identified as an extremely down-regulated gene in the genetic mutation mouse (Klotho mouse) of which phenotype is very similar to various symptoms of human aging.
WebNov 19, 2024 · Genetic inhibition of α-Klotho in vivo disrupted muscle progenitor cell (MPC) lineage progression and impaired myofiber regeneration, revealing a critical role for α-Klotho in the regenerative cascade. Genetic silencing of Klotho in young MPCs drove mitochondrial DNA (mtDNA) damage and decreased cellular bioenergetics. WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. Our RabMAb ® technology is a patented hybridoma-based technology ...
WebApr 4, 2012 · Recombinant human Klotho protein (Active) See all Klotho proteins and peptides Biological activity Determined by the dose-dependent stimulation of the proliferation of murine NIH/3T3 cells. ab84072 is effective in a concentration range of 0.5-2.0 μg/ml. Purity > 98 % SDS-PAGE. > 98% HPLC analyses. Endotoxin level < 1.000 Eu/µg …
WebAlpha-klotho attaches (binds) to and turns on (activates) a protein called FGF receptor 1 that spans the membrane of many types of cells, including kidney cells. Once the receptor is … hepatitis a and b immunizationsWebMar 29, 2024 · Researchers reveal the molecular structure of the so-called 'anti-aging' protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a … hepatitis a and b contagiousWebKlotho ELISA Kits. ELISA Kits detecting Klotho can be used to research aging and bone loss or to study chronic renal failure (CRF). Klotho, also known as alpha-kl, is a full name of Klotho. Your search returned 416 Klotho ELISA Kit across 25 suppliers. hepatitis a and b vaccine schedule adultWebα-Klotho protein (KL) has been discovered more than 20 years ago, and immediately emerged as a master regulator of aging-related processes, which basically operates as an … hepatitis a and b symptomsWebOct 22, 2024 · Klotho family members include α-, β-, and γ-klotho genes based on their predicted primary sequences [ 18, 19 ]. β- and γ-klotho were discovered based on their homology with α-klotho, and they all share a single-pass transmembrane protein [ 20, 21 ]. β-Klotho is predominantly expressed in the liver but is also found in the kidney, gut, and … hepatitis a and b vaccine indicationsWebJan 21, 2024 · Klotho encodes alpha-Klotho (αKl) that possesses a single-pass transmembrane domain and is expressed in the distal tubule of kidneys, parathyroid … hepatitis a and b immunizationWebJul 16, 2024 · As a co-receptor for fibroblast growth factor 23, klotho plays a pivotal role in phosphate metabolism. The kidney is known to be the main source of soluble alpha-klotho and the principal regulator of its concentration. Previous studies in human participants showed that the concentration of soluble alpha-klotho in serum and urine decreased in … hepatitis a and b vaccines schedule