WebOct 1, 2005 · The ciliary rootlet is a large striated fibrous network originating from basal bodies in ciliated cells. To explore its postulated role in intracellular transport, we investigated the interaction between kinesin light chains (KLCs) and rootletin, the structural component of ciliary rootlets. WebRootletin. Rootletin also known as ciliary rootlet coiled-coil protein (CROCC) is a protein that in humans is encoded by the CROCC gene. [1] [2] [3] Rootletin is a component of the ciliary rootlet, and, together with CEP68 and CEP250, is required for centrosome cohesion. [4]
Rootletin, a novel coiled-coil protein, is a structural component of ...
WebNov 11, 2002 · Rootletin in the retina was primarily derived from photoreceptor cells because its level was greatly diminished in rd mouse retinas in which the photoreceptors had degenerated (unpublished data). Rootletin was found in the insoluble fraction of cell … WebMar 13, 2007 · Rootletin, the structural constituent of the ciliary rootlet and separated from the connecting cilia only by a basal body, marks the proximal boundary of the connecting cilia ( 29 ). RP1, on the other hand, associates with the axonemal microtubules in the basal outer segments and marks the distal boundary of the connecting cilia ( 30, 31 ). matthew pendergast
Retinal diseases - Symptoms and causes - Mayo Clinic
WebTwo membrane forms of RetGCs are expressed specifically in the retina of several mammalian species, including humans. 245–248 Whereas other membrane cyclases are activated by the binding of peptide ligands to their extracellular domains, the activity of RetGCs is controlled by interaction with GCAPs through their intracellular domain. 249,250 … WebMar 31, 2016 · Rootletin shares significant structural similarity with the centrosomal protein Cnap1 (CEP2; 609689). Western blot analysis detected rootletin at an apparent molecular … WebNov 11, 2002 · Rootletin in the retina was primarily derived from photoreceptor cells because its level was greatly diminished in rd mouse retinas in which the photoreceptors had degenerated (unpublished data). Rootletin was found in … matthew pender md