Small vcp/p97-interacting protein expression

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August undefined, 2024

WebUsing substrate trapping in vitro and in vivo in the human Ewing sarcoma TC32 cell line, they identified valosin-containing protein (VCP/p97) as a new PTPN13 substrate. As VCP/p97 phosphorylation is necessary for PTPN13 midbody localization during cell division, a PTPN13 pro-oncogenic role in Ewing sarcoma, mediated through regulation of cell ... WebY. Amagasaki is an academic researcher. The author has contributed to research in topic(s): Precipitin & Antigen. The author has an hindex of 1, co-authored 1 publication(s) receiving 10 citation(s).

Yi-Ping Hsueh Institute of Molecular Biology, Academia Sinica

WebOct 11, 2013 · VCP, also named p97 or cdc48, executes diverse functions by association of this ATPase with over 40 different adaptor proteins (cofactors). These interactions typically depend on specific protein domains in both VCP and cofactors. WebNov 18, 2002 · A bacterial expression plasmid for N-terminally hexahistidine-tagged VCP/p97 (His-VCP/p97) was constructed by subcloning the full-length cDNA of rat … song lyrics through the fire

Valosin-containing protein - Wikipedia

WebDihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines WebThe AAA (ATPase associated with various cellular activities) ATPase p97, also referred to as valosin-containing protein (VCP), mediates essential cellular processes, including ubiquitin-dependent protein degradation, and has been linked to several human proteinopathies. p97 interacts with multiple cofactors via its N-terminal (p97N) domain, a subset of which … WebThe encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B … song lyrics time is on my side

Structure and expression of a novel compact myelin …

Entry - *611745 - VCP/p47 COMPLEX-INTERACTING PROTEIN 1; VCPIP1 …

WebSVIP → Small VCP/p97-interacting protein Gene name : SVIP Family name : SVIP Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. INTERACTIONS Interacts (via VIM motif) with VCP. • gold 1 ev UniProt GO MOLECULAR … WebEl gen SVIP (Small VCP/p97-Interacting Protein) codifica por una proteína que es un inhibidor de la degradación del retículo endoplasmático que también participa en la … song lyrics time of the seasonWebAug 7, 2024 · The aim of the study was to investigate the expressions of SVIP, p97/VCP, StAR, CYP17A1 and 3β-HSD in human and mouse. Methods and results HLC, TM3 and MA … smallest ladies smart watch

"WebNov 18, 2002 · A bacterial expression plasmid for N-terminally hexahistidine-tagged VCP/p97 (His-VCP/p97) was constructed by subcloning the full-length cDNA of rat VCP/p97 into pQE30 (QIAGEN). The bacterial expression plasmid for N-terminally hexahistidine-tagged Ufd1p (His-Ufd1p) was kindly donated by Dr. G. Warren. " - Small vcp/p97-interacting protein expression

Small vcp/p97-interacting protein expression

Entry - *611745 - VCP/p47 COMPLEX-INTERACTING PROTEIN 1; VCPIP1 …

WebWhile, VCP function was inhibited by small molecule VCP inhibitor Eeyarestatin I (EerI) [18] at a final concentration of 10 mM for 24 hrs and compared to DMSO control vehicle. The pcDNA3.1-VCP-myc and control plasmids were transfected as above for over expression experiments. Immunofluorescence Microscopy of Clinical Biopsies from NSCLC Patients- WebOct 11, 2013 · SVIP (small p97/VCP-interacting protein) was initially identified as one of many cofactors regulating the valosin containing protein (VCP), an AAA+ ATPase involved in endoplasmic-reticulum-associated protein degradation (ERAD). Our previous study showed that SVIP is expressed exclusively in the nervous system.

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WebUsing proteomic approaches, we identified VCP/p97 (valosin containing protein) as a novel neurofibromin interacting protein. The experiments combining cultured neurons and mouse genetic model suggest that VCP/p97 acts downstream of neurofibromin in controlling neuronal morphogenesis. WebValosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase (TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. The …

WebAug 31, 2011 · The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in HeLa cells leads to localization of p97/VCP at the plasma membrane, intracellular foci and juxtanuclear vacuoles. WebJan 18, 2024 · VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. The AAA+-type ATPase p97 governs an ever-expanding number of cellular …

WebVCP stimulates the deubiquitinase activity of ATXN3 (ataxin 3) to stabilize BECN1 protein levels and also interacts with and promotes the assembly and kinase activity of the … WebFeb 9, 2024 · Valosin containing protein (VCP) has emerged as a central protein in the regulation of the protein quality control (PQC) system. VCPmutations are causative of multisystem proteinopathies, which include neurodegenerative diseases (NDs), and share various signs of altered proteostasis, mainly associated with autophagy malfunctioning.

WebApr 11, 2024 · The mRNA expression levels of HRD1, gp78, E3 ligase enzymes; p97/VCP, retrotranslocation protein; UFD1L and NPL4, cofactor proteins; OS9, ER lectin protein and UFD2A which functions as ubiquitin-chain elongation factor E3/E4 ubiquitin ligase were significantly up-regulated by dexamethasone induction in a dose-dependent manner (Fig. …

WebOct 11, 2013 · SVIP (small p97/VCP-interacting protein) was initially identified as one of many cofactors regulating the valosin containing protein (VCP), an AAA+ ATPase … song lyrics till the storm passes byWebMicroinjection of antibodies against Vcip135 and p47 in rat kidney cells showed that Vcip135 and p47 were required for Golgi and endoplasmic reticulum assembly. Wang et al. (2004) found that p97/p47-mediated reassembly of Golgi cisternae required ubiquitin. They identified rat Vcip135 as a deubiquitinating enzyme and found that it reversed the ... song lyrics time of your lifeWebSmall p97/VCP-interacting protein (SVIP) was first discovered as one of the novel androgen-responsive genes as well as one of the many cofactors controlling p97/VCP. The aim of … smallest lake in indiaWebHere we find that compounds that activate the D1 ATPase activity of VCP/p97 fulfill these requirements. Such effects are seen with small molecule VCP activators like SMER28, which activate autophagosome biogenesis by enhancing interactions of PI3K complex components to increase PI(3)P production, and also accelerate VCP-dependent … song lyrics time in a bottleWebJan 18, 2024 · p97/VCP (CDC48p in yeast) is a highly abundant molecular chaperone that functions in diverse cellular processes such as ubiquitin-dependent proteolysis, retrograde transport of protein from... song lyrics ting ting like glitter and goldWebProtein names Recommended name Small VCP/p97-interacting protein Gene names Name SVIP Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI … song lyrics time pink floydWebMar 1, 2024 · Small p97/VCP-interacting protein (SVIP) is an interacting cofactor that regulates the p97/valosin containing protein (VCP), an AAA + ATPase involved in the … song lyrics time for a cool change